The Telemetry Laboratory is an integral part of the research infrastructure dedicated to
large animal models. It enables long-term, non-invasive monitoring
of selected physiological parameters using advanced telemetry systems.
Following the implantation of appropriate electrodes or sensors,
signals can be recorded from various organ systems,
including gastrointestinal motility, uterine contractility, bladder activity,
as well as cardiovascular, respiratory, and neurophysiological parameters.
Telemetry systems allow for continuous and precise data collection in real time
without the need to restrain animals or limit their natural behavior.
Animals can be housed individually or in groups, in cages adapted
to receive either radio or digital signals. This approach allows
studies to be conducted under conditions that closely resemble physiological norms,
while maintaining a high standard of animal welfare.
Telemetry is widely used in studies involving:
Pharmacology and toxicology – enabling continuous, highly sensitive assessment
of the effects of biologically active substances on organ function,
Neurophysiology and behavioral research – allowing analysis of circadian rhythms,
postoperative activity changes, social behavior, and responses to stress and pain,
Surgical and preclinical procedures – enabling evaluation of the physiological
impact of specific surgical interventions (e.g., nerve injury, CNS manipulation,
organ procedures),
Reproductive and gynecological studies – facilitating the recording of uterine
contractions, hormonal activity, and responses to pharmacological stimulation.
Data can be collected continuously over several days, weeks, or even months, making
telemetry an exceptionally valuable tool for long-term
translational research.
The laboratory is equipped with modern receiver stations and analytical software
that enables precise data processing, synchronization with
other recording systems, and integration with histopathological,
imaging, and molecular data.
In addition, the telemetry laboratory is equipped with a Radnoti Tissue Bath System,
which allows for in vitro assessment of tissue activity using samples obtained either ante mortem
or post mortem. This enables the collection of valuable complementary data
to in vivo telemetry studies, derived from
a highly controlled laboratory environment.
The system comprises two interchangeable sets of four baths (50 ml and 25 ml),
a reservoir for physiological buffer solution, a temperature-controlled water jacket system,

buffer aeration, platinum electrodes for electromagnetic stimulation of samples,
and transducers for measuring isotonic contractions.
The entire setup is managed via an analytical station
integrated with a computer system.
Thanks to its sophisticated design aimed at maintaining tissue stability under near- physiological conditions,
the system delivers highly reproducible results, particularly valuable
in pharmacological and toxicological studies.